- The Early Person who Diagnosed with Alzheimer’s Diseases - Part 1 – Alzheimer's 2
He found “dramatic brain shrinkage and abnormal deposits in and around nerve cells.”
Brain shrinkage and the abnormal deposit in this day are called amyloid plaques and neurofibrillary tangles.
From the picture, the yellow color are neurofibrillary tangles, and brown dark are amyloid plaques.
Specifically, it is in the neocortex, amygdala, and brainstem
The causes of Alzheimer's Disease is not fully understand yet.
There are three principle features could be detected in every person who severe with the Alzheimer's disease:
1) Collection of intra-neuronal cytoskeletal filaments or neurofibrillary tangles, also we know as aggregate tau protein in the brain.
2) extracellular deposit of an abnormal amyloid or amyloid plaques.
3) A diffuse loss of neurons.
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